Potential involvement of semaphorin 3A in maintaining intervertebral disc tissue homeostasis
نویسندگان
چکیده
منابع مشابه
Expression of semaphorin 3A and its receptors in the human intervertebral disc: potential role in regulating neural ingrowth in the degenerate intervertebral disc
INTRODUCTION Intervertebral disc (IVD) degeneration is considered a major underlying factor in the pathogenesis of chronic low back pain. Although the healthy IVD is both avascular and aneural, during degeneration there is ingrowth of nociceptive nerve fibres and blood vessels into proximal regions of the IVD, which may contribute to the pain. The mechanisms underlying neural ingrowth are, howe...
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OBJECTIVES Semaphorin 3A (sema3A) plays a regulatory role in immune responses with effects on both T and B regulatory cells. Familial Mediterranean fever (FMF) is an autoinflammatory disease, yet a possible role for regulatory T and B cells has been described. METHODS 17 FMF patients during attack and then in remission, 8 FMF patients with smoldering disease and 12 healthy controls were enrol...
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Low back pain, which is often caused by disc degeneration, is a major health problem. Due to the limitations of the current treatments for degenerative disc disease, tissue engineering methods have been proposed. These methods present the opportunity to restore the functionality of the intervertebral disc by repairing or replacing the degenerated tissue. One of the major challenges in intervert...
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Background: A large proportion of patients presenting with lumbar disc disease are opium addicts in our region. It was, therefore, hypothesized that morphine might affect the intervertebral disc. We investigated the histological findings of morphine dependency on intervertebral discs in rat. Methods: Forty NMRI adult male rats (230-250 g) placed on ordinary diet and received aqueous solution of...
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Degenerative spinal disorders including low back pain are one of the most common and costly problems for modern society. It has been recognized that these disorders are directly or indirectly associated with intervertebral disc degeneration. The disc is a cartilaginous connective tissue, composed of the nucleus pulposus(NP), annulus fibrosus and endplates, which connects adjacent vertebrae (the...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2019
ISSN: 0736-0266,1554-527X
DOI: 10.1002/jor.24258